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Acquired immunodeficiency syndrome and Epstein-Barr virus.
- Source :
-
International journal of STD & AIDS [Int J STD AIDS] 1990 Sep; Vol. 1 (5), pp. 318-20. - Publication Year :
- 1990
-
Abstract
- Epstein-Barr virus is an important aetiological factor in certain HIV-related syndromes, with its opportunist expression related to the level of host immunodeficiency. In asymptomatic people co-infected with HIV, EBV activity is reflected by increased viral shedding and rises in anti-EBV titres; as immunodeficiency ensues EBV manifests as epithelial hyperproliferation in OHL, and later as B-cell lymphoma in AIDS. The suggested role of EBV as a co-factor in the progression of HIV infection and development of AIDS has not been established, although another herpesvirus, cytomegalovirus, might play such a role. Advances in our understanding of HIV regulation and its interaction with other latent (herpes) viruses should provide important molecular and pharmacological approaches to the clinical management of advanced HIV disease.
- Subjects :
- Acquired Immunodeficiency Syndrome etiology
B-Lymphocytes immunology
B-Lymphocytes microbiology
Esophageal Neoplasms etiology
HIV pathogenicity
Humans
Immune Tolerance
Leukoplakia etiology
Lymphoproliferative Disorders etiology
Mouth Neoplasms etiology
Acquired Immunodeficiency Syndrome complications
Herpesviridae Infections complications
Herpesvirus 4, Human
Subjects
Details
- Language :
- English
- ISSN :
- 0956-4624
- Volume :
- 1
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- International journal of STD & AIDS
- Publication Type :
- Editorial & Opinion
- Accession number :
- 1965885
- Full Text :
- https://doi.org/10.1177/095646249000100502