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Porous scaffolds of polycaprolactone reinforced with in situ generated hydroxyapatite for bone tissue engineering.

Authors :
Fabbri P
Bondioli F
Messori M
Bartoli C
Dinucci D
Chiellini F
Source :
Journal of materials science. Materials in medicine [J Mater Sci Mater Med] 2010 Jan; Vol. 21 (1), pp. 343-51. Date of Electronic Publication: 2009 Aug 04.
Publication Year :
2010

Abstract

Polycaprolactone/hydroxyapatite (PCL/HA) composites were prepared by in situ generation of HA in the polymer solution starting from the precursors calcium nitrate tetrahydrate and ammonium dihydrogen phosphate via sol-gel process. Highly interconnected porosity was achieved by means of the salt-leaching technique using a mixture of sodium chloride and sodium bicarbonate as porogens. Structure and morphology of the PCL/HA composites were investigated by scanning electron microscopy, and mechanical properties were determined by means of tensile and compression tests. The possibility to employ the developed composites as scaffolds for bone tissue regeneration was assessed by cytotoxicity test of the PCL/HA composites extracts and cell adhesion and proliferation in vitro studies.

Details

Language :
English
ISSN :
1573-4838
Volume :
21
Issue :
1
Database :
MEDLINE
Journal :
Journal of materials science. Materials in medicine
Publication Type :
Academic Journal
Accession number :
19653069
Full Text :
https://doi.org/10.1007/s10856-009-3839-5