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Porous scaffolds of polycaprolactone reinforced with in situ generated hydroxyapatite for bone tissue engineering.
- Source :
-
Journal of materials science. Materials in medicine [J Mater Sci Mater Med] 2010 Jan; Vol. 21 (1), pp. 343-51. Date of Electronic Publication: 2009 Aug 04. - Publication Year :
- 2010
-
Abstract
- Polycaprolactone/hydroxyapatite (PCL/HA) composites were prepared by in situ generation of HA in the polymer solution starting from the precursors calcium nitrate tetrahydrate and ammonium dihydrogen phosphate via sol-gel process. Highly interconnected porosity was achieved by means of the salt-leaching technique using a mixture of sodium chloride and sodium bicarbonate as porogens. Structure and morphology of the PCL/HA composites were investigated by scanning electron microscopy, and mechanical properties were determined by means of tensile and compression tests. The possibility to employ the developed composites as scaffolds for bone tissue regeneration was assessed by cytotoxicity test of the PCL/HA composites extracts and cell adhesion and proliferation in vitro studies.
- Subjects :
- Animals
BALB 3T3 Cells
Biomechanical Phenomena
Bone and Bones cytology
Bone and Bones drug effects
Cell Adhesion drug effects
Cell Adhesion physiology
Cell Proliferation drug effects
Cells, Cultured
Durapatite chemical synthesis
Materials Testing
Mice
Microscopy, Electron, Transmission
Phase Transition
Porosity
Tissue Engineering methods
Water pharmacology
Bone and Bones physiology
Durapatite chemistry
Polyesters chemistry
Tissue Scaffolds chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1573-4838
- Volume :
- 21
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of materials science. Materials in medicine
- Publication Type :
- Academic Journal
- Accession number :
- 19653069
- Full Text :
- https://doi.org/10.1007/s10856-009-3839-5