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Pravastatin and cognitive function in the elderly. Results of the PROSPER study.
- Source :
-
Journal of neurology [J Neurol] 2010 Jan; Vol. 257 (1), pp. 85-90. Date of Electronic Publication: 2009 Aug 04. - Publication Year :
- 2010
-
Abstract
- Observational studies have given conflicting results about the effect of statins in preventing dementia and cognitive decline. Moreover, observational studies are subject to prescription bias, making it hard to draw definite conclusions from them. Randomized controlled trials are therefore the preferred study design to investigate the association between statins and cognition. Here we present detailed cognitive outcomes from the randomized placebo-controlled PROspective Study of Pravastatin in the Elderly at Risk (PROSPER). Cognitive function was assessed repeatedly in all 5,804 PROSPER participants at six different time points during the study using four neuropsychological performance tests. After a mean follow-up period of 42 months, no difference in cognitive decline at any of the cognitive domains was found in subjects treated with pravastatin compared to placebo (all p > 0.05). Pravastatin treatment in old age did not affect cognitive decline during a 3 year follow-up period. Employing statin therapy in the elderly in an attempt to prevent cognitive decline therefore seems to be futile.
- Subjects :
- Aged
Anticholesteremic Agents therapeutic use
Female
Follow-Up Studies
Humans
Male
Neuropsychological Tests
Prospective Studies
Time Factors
Treatment Outcome
Aging drug effects
Cognition drug effects
Cognition Disorders drug therapy
Cognition Disorders prevention & control
Nootropic Agents therapeutic use
Pravastatin therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1432-1459
- Volume :
- 257
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of neurology
- Publication Type :
- Academic Journal
- Accession number :
- 19653027
- Full Text :
- https://doi.org/10.1007/s00415-009-5271-7