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CT-X antigen expression in human breast cancer.
- Source :
-
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2009 Aug 11; Vol. 106 (32), pp. 13493-8. Date of Electronic Publication: 2009 Jul 27. - Publication Year :
- 2009
-
Abstract
- Cancer/testis (CT) genes are predominantly expressed in human germ line cells, but not somatic tissues, and frequently become activated in different cancer types. Several CT antigens have already proved to be useful biomarkers and are promising targets for therapeutic cancer vaccines. The aim of the present study was to investigate the expression of CT antigens in breast cancer. Using previously generated massively parallel signature sequencing (MPSS) data, together with 9 publicly available gene expression datasets, the expression pattern of CT antigens located on the X chromosome (CT-X) was interrogated. Whereas a minority of unselected breast cancers was found to contain CT-X transcripts, a significantly higher expression frequency was detected in estrogen and progesterone receptor (ER) negative breast cancer cell lines and primary breast carcinomas. A coordinated pattern of CT-X antigen expression was observed, with MAGEA and NY-ESO-1/CTAG1B being the most prevalent antigens. Immunohistochemical staining confirmed the correlation of CT-X antigen expression and ER negativity in breast tumors and demonstrated a trend for their coexpression with basal cell markers. Because of the limited therapeutic options for ER-negative breast cancers, vaccines based on CT-X antigens might prove to be useful.
- Subjects :
- Antigens, Neoplasm metabolism
Breast Neoplasms classification
Breast Neoplasms immunology
Breast Neoplasms pathology
Expressed Sequence Tags
Female
Humans
Immunohistochemistry
Membrane Proteins genetics
Neoplasm Metastasis pathology
Receptors, Estrogen metabolism
Receptors, Progesterone metabolism
Tissue Array Analysis
Antigens, Neoplasm genetics
Breast Neoplasms genetics
Gene Expression Regulation, Neoplastic
Subjects
Details
- Language :
- English
- ISSN :
- 1091-6490
- Volume :
- 106
- Issue :
- 32
- Database :
- MEDLINE
- Journal :
- Proceedings of the National Academy of Sciences of the United States of America
- Publication Type :
- Academic Journal
- Accession number :
- 19651608
- Full Text :
- https://doi.org/10.1073/pnas.0906840106