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Hepatitis C virus utilizes lipid droplet for production of infectious virus.
- Source :
-
Proceedings of the Japan Academy. Series B, Physical and biological sciences [Proc Jpn Acad Ser B Phys Biol Sci] 2009; Vol. 85 (7), pp. 217-28. - Publication Year :
- 2009
-
Abstract
- Hepatitis C virus (HCV) establishes a persistent infection and causes chronic hepatitis. Chronic hepatitis patients often develop hepatic cirrhosis and progress to liver cancer. The development of this pathological condition is linked to the persistent infection of the virus. In other words, viral replication/multiplication may contribute to disease pathology. Accumulating clinical studies suggest that HCV infection alters lipid metabolism, and thus causes fatty liver. It has been reported that this abnormal metabolism exacerbates hepatic diseases. Recently, we revealed that lipid droplets play a key role in HCV replication. Understanding the molecular mechanism of HCV replication will help elucidate the pathogenic mechanism and develop preventive measures that inhibit disease manifestation by blocking persistent infection. In this review, we outline recent findings on the function of lipid droplets in the HCV replication cycle and describe the relationship between the development of liver diseases and virus replication.
- Subjects :
- Animals
Cells cytology
Cells drug effects
Cells metabolism
Detergents pharmacology
Hepacivirus drug effects
Hepacivirus genetics
Hepacivirus growth & development
Humans
Lipid Metabolism drug effects
Viral Proteins chemistry
Viral Proteins metabolism
Virus Replication drug effects
Hepacivirus physiology
Lipid Metabolism physiology
Virus Replication physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1349-2896
- Volume :
- 85
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Proceedings of the Japan Academy. Series B, Physical and biological sciences
- Publication Type :
- Academic Journal
- Accession number :
- 19644222
- Full Text :
- https://doi.org/10.2183/pjab.85.217