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On a path to unfolding the biological mechanisms of orthodontic tooth movement.
- Source :
-
Journal of dental research [J Dent Res] 2009 Jul; Vol. 88 (7), pp. 597-608. - Publication Year :
- 2009
-
Abstract
- Orthodontic forces deform the extracellular matrix and activate cells of the paradental tissues, facilitating tooth movement. Discoveries in mechanobiology have illuminated sequential cellular and molecular events, such as signal generation and transduction, cytoskeletal re-organization, gene expression, differentiation, proliferation, synthesis and secretion of specific products, and apoptosis. Orthodontists work in a unique biological environment, wherein applied forces engender remodeling of both mineralized and non-mineralized paradental tissues, including the associated blood vessels and neural elements. This review aims at identifying events that affect the sequence, timing, and significance of factors that determine the nature of the biological response of each paradental tissue to orthodontic force. The results of this literature review emphasize the fact that mechanoresponses and inflammation are both essential for achieving tooth movement clinically. If both are working in concert, orthodontists might be able to accelerate or decelerate tooth movement by adding adjuvant methods, whether physical, chemical, or surgical.
- Subjects :
- Alveolar Process cytology
Alveolar Process physiology
Animals
Biomechanical Phenomena
Bone Remodeling
Extracellular Fluid physiology
Extracellular Matrix physiology
Gene Expression
Gingiva cytology
Gingiva physiology
Humans
Inflammation physiopathology
Mechanoreceptors physiology
Neovascularization, Physiologic
Osteocytes physiology
Periodontal Ligament cytology
Periodontal Ligament physiology
Signal Transduction
Dental Stress Analysis
Tooth Movement Techniques
Subjects
Details
- Language :
- English
- ISSN :
- 1544-0591
- Volume :
- 88
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Journal of dental research
- Publication Type :
- Academic Journal
- Accession number :
- 19641146
- Full Text :
- https://doi.org/10.1177/0022034509338914