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Transgenic Plasmodium knowlesi: relieving a bottleneck in malaria research?
- Source :
-
Trends in parasitology [Trends Parasitol] 2009 Aug; Vol. 25 (8), pp. 370-4. Date of Electronic Publication: 2009 Jul 25. - Publication Year :
- 2009
-
Abstract
- Plasmodium knowlesi is a primate malaria parasite that is phylogenetically close to the major human parasite Plasmodium vivax. P. knowlesi causes life-threatening disease in humans, infects a wide range of non-human primates and is one of few malaria parasites amenable to cyclical in vitro propagation. A robust in vivo and in vitro genetic manipulation system has been developed for this parasite, enabling in vitro-in vivo shuttling of transgenes, which (together with recent characterization of its genome and that of its macaque experimental host) offers unique opportunities to gain insight in molecular function and parasite-host interactions.
- Subjects :
- Animals
Genomics
Humans
Macaca mulatta
Proteomics
Disease Models, Animal
Erythrocytes parasitology
Host-Parasite Interactions
Malaria parasitology
Malaria physiopathology
Organisms, Genetically Modified
Plasmodium knowlesi genetics
Plasmodium knowlesi growth & development
Plasmodium knowlesi pathogenicity
Plasmodium knowlesi physiology
Research Design
Subjects
Details
- Language :
- English
- ISSN :
- 1471-5007
- Volume :
- 25
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Trends in parasitology
- Publication Type :
- Academic Journal
- Accession number :
- 19635679
- Full Text :
- https://doi.org/10.1016/j.pt.2009.05.009