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Pentobarbital blocks the stress-induced decrease in [3H]Ro 5-4864 binding in rat kidney.
- Source :
-
Brain research [Brain Res] 1990 Dec 03; Vol. 535 (1), pp. 151-4. - Publication Year :
- 1990
-
Abstract
- Exposure to environmental stress causes changes in the binding of [3H]Ro 5-4864 to peripheral benzodiazepine receptors (PBRs). The influence of the central nervous system (CNS) in these stress-induced modifications is unclear. The present study examined whether pretreatment with a dose-response regimen of sodium pentobarbital would impact the stress-induced reduction in renal PBR. Administration of either a sedative/ataxic (20 mg/kg) or hypnotic (60 mg/kg) dose of pentobarbital prior to stress blocks the stress-induced decrease of [3H]Ro 5-4864 binding to renal PBR in rat. These findings suggest that higher-order, supraspinal mechanisms play a critical role in marshalling the renal PBR changes in response to stress.
- Subjects :
- Animals
Benzodiazepinones
Dose-Response Relationship, Drug
Kidney drug effects
Male
Pain Measurement methods
Radioligand Assay
Rats
Rats, Inbred Strains
Reaction Time drug effects
Tritium
Kidney metabolism
Pentobarbital pharmacology
Receptors, GABA-A metabolism
Stress, Physiological metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0006-8993
- Volume :
- 535
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Brain research
- Publication Type :
- Academic Journal
- Accession number :
- 1963342
- Full Text :
- https://doi.org/10.1016/0006-8993(90)91834-4