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Functional connectivity and alterations in baseline brain state in humans.
- Source :
-
NeuroImage [Neuroimage] 2010 Jan 01; Vol. 49 (1), pp. 823-34. Date of Electronic Publication: 2009 Jul 22. - Publication Year :
- 2010
-
Abstract
- This work examines the influence of changes in baseline activity on the intrinsic functional connectivity fMRI (fc-fMRI) in humans. Baseline brain activity was altered by inducing anesthesia (sevoflurane end-tidal concentration 1%) in human volunteers and fc-fMRI maps between the pre-anesthetized and anesthetized conditions were compared across different brain networks. We particularly focused on low-level sensory areas (primary somatosensory, visual, and auditory cortices), the thalamus, and pain (insula), memory (hippocampus) circuits, and the default mode network (DMN), the latter three to examine higher-order brain regions. The results indicate that, while fc-fMRI patterns did not significantly differ (p<0.005; 20-voxel cluster threshold) in sensory cortex and in the DMN between the pre- and anesthetized conditions, fc-fMRI in high-order cognitive regions (i.e. memory and pain circuits) was significantly altered by anesthesia. These findings provide further evidence that fc-fMRI reflects intrinsic brain properties, while also demonstrating that 0.5 MAC sevoflurane anesthesia preferentially modulates higher-order connections.
- Subjects :
- Adult
Anesthesia
Anesthetics, Inhalation
Brain Mapping
Female
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Methyl Ethers
Nerve Net anatomy & histology
Nerve Net physiology
Neural Pathways anatomy & histology
Pain physiopathology
Pain psychology
Sevoflurane
Young Adult
Brain physiology
Neural Pathways physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1095-9572
- Volume :
- 49
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- NeuroImage
- Publication Type :
- Academic Journal
- Accession number :
- 19631277
- Full Text :
- https://doi.org/10.1016/j.neuroimage.2009.07.028