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B-Alkylcatecholborane-mediated tandem radical conjugated addition-aldol cyclization.

Authors :
Beauseigneur A
Ericsson C
Renaud P
Schenk K
Source :
Organic letters [Org Lett] 2009 Aug 20; Vol. 11 (16), pp. 3778-81.
Publication Year :
2009

Abstract

A one-pot procedure involving radical conjugate addition of B-alkylcatecholboranes to enones followed by intramolecular aldol reaction is reported. Application to the stereoselective synthesis of monocyclic and bicyclic products with up to four contiguous stereogenic centers is presented.

Details

Language :
English
ISSN :
1523-7052
Volume :
11
Issue :
16
Database :
MEDLINE
Journal :
Organic letters
Publication Type :
Academic Journal
Accession number :
19630429
Full Text :
https://doi.org/10.1021/ol9014943