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Red blood cell (RBC) membrane proteomics--Part II: Comparative proteomics and RBC patho-physiology.
- Source :
-
Journal of proteomics [J Proteomics] 2010 Jan 03; Vol. 73 (3), pp. 421-35. Date of Electronic Publication: 2009 Jul 19. - Publication Year :
- 2010
-
Abstract
- Membrane proteomics offers unprecedented possibilities to compare protein expression in health and disease leading potentially to the identification of markers, of targets for therapeutics and to a better understanding of disease mechanisms. From transfusion medicine to infectious diseases, from cardiovascular affections to diabetes, comparative proteomics has made a contribution to the identification of proteins unique to RBCs of patients with specific illnesses shedding light on possible RBC markers for systemic diseases. In this review we will provide a short overview of some of the main achievements obtained by comparative proteomics in the field of RBC-related local and systemic diseases and suggest some additional areas of RBCs research to which comparative proteomics approaches could be fruitfully applied or extended in combination with biochemical techniques.<br /> ((c) 2009 Elsevier B.V. All rights reserved.)
- Subjects :
- Anemia pathology
Anemia physiopathology
Animals
Blood Transfusion methods
Blood Transfusion statistics & numerical data
Disease
Erythrocytes physiology
Homeostasis physiology
Humans
Models, Biological
Transplantation, Heterologous methods
Erythrocyte Membrane metabolism
Erythrocytes metabolism
Erythrocytes pathology
Proteomics methods
Subjects
Details
- Language :
- English
- ISSN :
- 1876-7737
- Volume :
- 73
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of proteomics
- Publication Type :
- Academic Journal
- Accession number :
- 19622400
- Full Text :
- https://doi.org/10.1016/j.jprot.2009.07.004