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Male-specific expression of Aldh1a1 in mouse and chicken fetal testes: implications for retinoid balance in gonad development.
- Source :
-
Developmental dynamics : an official publication of the American Association of Anatomists [Dev Dyn] 2009 Aug; Vol. 238 (8), pp. 2073-80. - Publication Year :
- 2009
-
Abstract
- Balanced production and degradation of retinoids is important in regulating development of several organ systems in the vertebrate embryo. Among these, it is known that retinoic acid (RA), and the retinoid-catabolyzing enzyme CYP26B1 together regulate the sex-specific behavior of germ cells in developing mouse gonads. We report here that the gene encoding a cytosolic class-1 aldehyde dehydrogenase, ALDH1A1, a weak catalyst of RA production, is strongly expressed in a male-specific manner in somatic cells of the developing mouse testis, beginning shortly after Sry expression is first detectable. This expression pattern is conserved in the developing male gonad of the chicken and is dependent on the testis-specific transcription factor SOX9. Our data suggest that low levels of RA may be required for early developmental events in the testis, or that Aldh1a1 expression in the fetus may prefigure a later requirement for ALDH1A1 in regulating spermatogenesis postnatally.<br /> (Copyright (c) 2009 Wiley-Liss, Inc.)
- Subjects :
- Aldehyde Dehydrogenase metabolism
Aldehyde Dehydrogenase 1 Family
Animals
Base Sequence
Chick Embryo
DNA Primers genetics
Female
Gene Expression Regulation, Developmental
Genes, sry
Isoenzymes metabolism
Male
Mice
Mice, Transgenic
Pregnancy
Retinal Dehydrogenase
SOX9 Transcription Factor metabolism
Sex Differentiation
Testis metabolism
Tretinoin metabolism
Aldehyde Dehydrogenase genetics
Isoenzymes genetics
Retinoids metabolism
Testis embryology
Testis enzymology
Subjects
Details
- Language :
- English
- ISSN :
- 1058-8388
- Volume :
- 238
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Developmental dynamics : an official publication of the American Association of Anatomists
- Publication Type :
- Academic Journal
- Accession number :
- 19618468
- Full Text :
- https://doi.org/10.1002/dvdy.22024