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[Expression of hemokinin-1 in rat spinal cord after peripheral inflammation].
- Source :
-
Kokubyo Gakkai zasshi. The Journal of the Stomatological Society, Japan [Kokubyo Gakkai Zasshi] 2009 Jun; Vol. 76 (2), pp. 81-90. - Publication Year :
- 2009
-
Abstract
- Hemokinin-1 (HK-1) is a novel peptide described as a member of the tachykinin family. Substance P (SP), a representative member of the tachykinin family, has been well characterized and is thought to play a part in inflammation and pain. While several studies indicate that HK-1 is involved in inflammation and pain, the biological functions of HK-1 are not fully understood. In the present study we investigated the expression of HK-1 mRNA (TAC4) and SP mRNA (TAC1) in the dorsal spinal cord of rat after inducing peripheral inflammation by administering complete Freund's adjuvant (CFA) into the hind paw, using real-time RT-PCR. In the behavioral studies, the thresholds of withdrawal response of the hind paw to thermal stimulation significantly decreased on the ipsilateral side, but not on the contralateral side, 6 hours after CFA injection and thermal hyperalgesia persisted until 4 days after CFA injection. The level of HK-1 mRNA expression significantly increased on the bilateral sides of the dorsal spinal cord 6 hours after CFA injection and returned to the base level 1 day after injection. On the other hand, the level of SP mRNA expression did not change in the spinal cord 6 hours and 1 day after CFA injection. These results indicate that HK-1 may contribute to inflammatory pain, in the early phase, in a different manner from SP.
Details
- Language :
- Japanese
- ISSN :
- 0300-9149
- Volume :
- 76
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Kokubyo Gakkai zasshi. The Journal of the Stomatological Society, Japan
- Publication Type :
- Academic Journal
- Accession number :
- 19610586