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Cigarette smoking and endometrial cancer risk: the modifying effect of obesity.

Authors :
Polesel J
Serraino D
Zucchetto A
Lucenteforte E
Dal Maso L
Levi F
Negri E
Montella M
Franceschi S
Talamini R
La Vecchia C
Source :
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) [Eur J Cancer Prev] 2009 Nov; Vol. 18 (6), pp. 476-81.
Publication Year :
2009

Abstract

The objective of this study was to evaluate the association between cigarette smoking and endometrial cancer risk by investigating potential modifying effects of menopausal status, obesity, and exogenous hormones. We pooled data from three case-control studies with the same study design conducted in Italy and Switzerland between 1982 and 2006. Overall, 1446 incident endometrial cancers and 4076 hospital controls were enrolled. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using logistic regression models, conditioned on study and centre, and adjusted for age, period of interview, age at menarche, parity, and body mass index. In comparison with never smokers, current smokers showed reduced endometrial cancer risk (OR: 0.80; 95% CI: 0.66-0.96), with a 28% decrease in risk for smoking ≥ 20 cigarettes/day. The association did not vary according to menopausal status, oral contraceptive use, or hormone replacement therapy. However, heterogeneity emerged according to body mass index among postmenopausal women, with obese women showing the greatest risk reduction for current smoking (OR: 0.47; 95% CI: 0.27-0.81). In postmenopausal women, obesity turned out to be an important modifier of the association between cigarette smoking and the risk of endometrial cancer. This finding calls for caution in interpreting the favorable effects of cigarette smoking, considering the toxic and carcinogenic effects of tobacco.

Details

Language :
English
ISSN :
1473-5709
Volume :
18
Issue :
6
Database :
MEDLINE
Journal :
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)
Publication Type :
Academic Journal
Accession number :
19609212
Full Text :
https://doi.org/10.1097/CEJ.0b013e32832f9bc4