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Obesity promotes inflammation in periaortic adipose tissue and angiotensin II-induced abdominal aortic aneurysm formation.
- Source :
-
Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2009 Oct; Vol. 29 (10), pp. 1458-64. Date of Electronic Publication: 2009 Jul 16. - Publication Year :
- 2009
-
Abstract
- Objective: Obesity promotes macrophage infiltration into adipose tissue and is associated with increases in several cardiovascular diseases. Infusion of angiotensin II (AngII) to mice induces formation of abdominal aortic aneurysms (AAAs) with profound medial and adventitial macrophage infiltration. We sought to determine whether obesity promotes macrophage infiltration and proinflammatory cytokines in periaortic adipose tissue surrounding abdominal aortas and increases AngII-induced AAAs.<br />Methods and Results: Hypertrophied white adipocytes surrounded abdominal aortas, whereas brown adipocytes surrounded thoracic aortas of obese mice. mRNA abundance of macrophage proinflammatory chemokines and their receptors were elevated with obesity to a greater extent in abdominal compared to thoracic periaortic adipose tissue. Periaortic adipose tissue explants surrounding abdominal aortas of obese mice released greater concentrations of MCP-1 and promoted more macrophage migration than explants from thoracic aortas. Male C57BL/6 mice were fed a high-fat (HF) diet for 1, 2, or 4 months and then infused with AngII (1000 ng/kg/min) for 28 days. AAA incidence increased progressively with the duration of HF feeding (18%, 36%,and 60%, respectively). Similarly, AngII-infused ob/ob mice exhibited increased AAAs compared to lean controls (76% compared to 32%, respectively, P<0.05). Infusion of AngII to obese mice promoted further macrophage infiltration into periaortic and visceral adipose tissue, and obese mice exhibiting AAAs had greater macrophage content in visceral adipose tissue than mice not developing AAAs.<br />Conclusions: Increased macrophage accumulation in periaortic adipose tissue surrounding abdominal aortas of AngII-infused obese mice is associated with enhanced AAA formation.
- Subjects :
- Animals
Aorta, Abdominal pathology
Aorta, Thoracic pathology
Cell Movement
Cytokines biosynthesis
Dietary Fats administration & dosage
Insulin Resistance
Macrophages physiology
Male
Mice
Mice, Inbred C57BL
Obesity immunology
Obesity pathology
Systole
Adipose Tissue pathology
Angiotensin II pharmacology
Aortic Aneurysm, Abdominal etiology
Inflammation etiology
Obesity complications
Subjects
Details
- Language :
- English
- ISSN :
- 1524-4636
- Volume :
- 29
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Arteriosclerosis, thrombosis, and vascular biology
- Publication Type :
- Academic Journal
- Accession number :
- 19608970
- Full Text :
- https://doi.org/10.1161/ATVBAHA.109.192658