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Prostate specific antigen in women with menstrual disturbances and fibrocystic mastopathy.
- Source :
-
Journal of endocrinological investigation [J Endocrinol Invest] 2009 Nov; Vol. 32 (10), pp. 821-4. Date of Electronic Publication: 2009 Jul 14. - Publication Year :
- 2009
-
Abstract
- The objective of this study was to evaluate serum prostate specific antigen (PSA) levels in women with menstrual disturbances and fibrocystic mastopathy. A total of 114 women with fibrocystic breast disease with cysts <10 mm (group I), 62 with macrocysts >10 mm (group II) and 46 healthy volunteers, who served as control subjects, were recruited for this prospective study. Each patient underwent complete gynecological examination and had performed sonography of the breasts. Moreover menstrual pattern, serum levels of free and total PSA, LH, FSH, SHBG, PRL, estradiol, progesterone, TSH, T4, as well as serum total testosterone, were evaluated in each subject. We compared serum free and total PSA levels between women with different menstrual pattern within groups of women with micro- and macrocysts. We also evaluated correlations between serum free and total PSA and hormonal/descriptive variables. We found that, in group II, women with regular menses and polymenorrhea revealed significantly higher serum free PSA than women with oligomenorrhea and secondary amenorrhea. Moreover, we found a positive correlation between serum total testosterone and total PSA in the control group and between progesterone and total PSA in group II. Our data show that serum free PSA is increased in women with regular menstrual cycles and polymenorrhea. This later relationship refers to women with macrocysts. Further studies are required to clarify the relationships between serum PSA and menstrual disturbances in women with mastopathy.
- Subjects :
- Adolescent
Adult
Analysis of Variance
Estradiol blood
Female
Fluoroimmunoassay
Follicle Stimulating Hormone blood
Humans
Luteinizing Hormone blood
Middle Aged
Progesterone blood
Prolactin blood
Prospective Studies
Sex Hormone-Binding Globulin metabolism
Statistics, Nonparametric
Testosterone blood
Thyrotropin blood
Thyroxine blood
Fibrocystic Breast Disease blood
Menstrual Cycle blood
Menstruation Disturbances blood
Prostate-Specific Antigen blood
Subjects
Details
- Language :
- English
- ISSN :
- 1720-8386
- Volume :
- 32
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Journal of endocrinological investigation
- Publication Type :
- Academic Journal
- Accession number :
- 19602918
- Full Text :
- https://doi.org/10.3275/6427