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Let-7 repression leads to HMGA2 overexpression in uterine leiomyosarcoma.
- Source :
-
Journal of cellular and molecular medicine [J Cell Mol Med] 2009 Sep; Vol. 13 (9B), pp. 3898-905. Date of Electronic Publication: 2008 Oct 13. - Publication Year :
- 2009
-
Abstract
- Overexpression of HMGA2 is common in uterine leiomyomas (ULM). The expression of HMGA2 in its malignant counterpart - uterine leiomyosarcomas (ULMS) remains undetermined. Recently it has been shown that repression of HMGA2 by microRNA let-7s is a critical molecular regulatory mechanism associated with tumour growth in many tumours and cell types, including leiomyomas. To test whether HMGA2 and let-7s play a role in ULMS, we examined the levels of endogenous HMGA2 and let-7 expression and found a significant correlation between these two molecules in a case-matched cohort of human ULMS. We found that overexpression of HMGA2 and let-7-mediated HMGA2 repression is a relevant molecular alteration in ULMS. Disrupting the control of HMGA2 and let-7 pairs promotes ULMS cell growth in vitro.
- Subjects :
- Adult
Aged
Aged, 80 and over
Case-Control Studies
Cell Proliferation
Cohort Studies
Female
Humans
In Situ Hybridization
MicroRNAs antagonists & inhibitors
MicroRNAs genetics
Middle Aged
Gene Expression Regulation, Neoplastic
HMGA2 Protein biosynthesis
Leiomyosarcoma metabolism
MicroRNAs physiology
Uterine Neoplasms metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1582-4934
- Volume :
- 13
- Issue :
- 9B
- Database :
- MEDLINE
- Journal :
- Journal of cellular and molecular medicine
- Publication Type :
- Academic Journal
- Accession number :
- 19602040
- Full Text :
- https://doi.org/10.1111/j.1582-4934.2008.00541.x