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Let-7 repression leads to HMGA2 overexpression in uterine leiomyosarcoma.

Authors :
Shi G
Perle MA
Mittal K
Chen H
Zou X
Narita M
Hernando E
Lee P
Wei JJ
Source :
Journal of cellular and molecular medicine [J Cell Mol Med] 2009 Sep; Vol. 13 (9B), pp. 3898-905. Date of Electronic Publication: 2008 Oct 13.
Publication Year :
2009

Abstract

Overexpression of HMGA2 is common in uterine leiomyomas (ULM). The expression of HMGA2 in its malignant counterpart - uterine leiomyosarcomas (ULMS) remains undetermined. Recently it has been shown that repression of HMGA2 by microRNA let-7s is a critical molecular regulatory mechanism associated with tumour growth in many tumours and cell types, including leiomyomas. To test whether HMGA2 and let-7s play a role in ULMS, we examined the levels of endogenous HMGA2 and let-7 expression and found a significant correlation between these two molecules in a case-matched cohort of human ULMS. We found that overexpression of HMGA2 and let-7-mediated HMGA2 repression is a relevant molecular alteration in ULMS. Disrupting the control of HMGA2 and let-7 pairs promotes ULMS cell growth in vitro.

Details

Language :
English
ISSN :
1582-4934
Volume :
13
Issue :
9B
Database :
MEDLINE
Journal :
Journal of cellular and molecular medicine
Publication Type :
Academic Journal
Accession number :
19602040
Full Text :
https://doi.org/10.1111/j.1582-4934.2008.00541.x