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Effect of long-term administration of zinc after scrotal heating on mice spermatozoa and subsequent offspring quality.
- Source :
-
Andrologia [Andrologia] 2009 Aug; Vol. 41 (4), pp. 222-8. - Publication Year :
- 2009
-
Abstract
- This study was set to investigate whether the adverse effects of heat on spermatozoa and subsequent foetuses could be prevented by long-term zinc administration. The scrotums of animals were immersed in water at either 43 degrees C (heat group) or 23 degrees C (control group). Half of the heat and control mice were given 10 mg kg(-1) zinc every other day for 60 days and the others received sterile saline instead of zinc. Heat stress significantly reduced sperm motility, concentration, hypoosmotic swelling-water test (HOS-WT) positive and chromomycin A(3) (CMA(3)) negative spermatozoa at the first 15 days, and the greatest decrease occurred at 30 days (P < 0.05). Sperm motility, concentration and HOS-WT positive spermatozoa were also reduced initially in the zinc administered group, but we did not observe any further decrease in the above mentioned parameters on day 30 (P < 0.05). The weight of foetuses obtained from the females mated with paternal heat treatment males was significantly lower than that of the control group (P < 0.05) and long-term zinc therapy caused a partial recovery (P > 0.05). This study demonstrates that the adverse effects of hyperthermia on semen parameters may be prevented by zinc therapy. Likewise, long-term administration of zinc could improve quality of litter obtained from the females mated with scrotal heat treatment males.
- Subjects :
- Animals
Female
Fetus drug effects
Male
Mice
Pregnancy
Pregnancy Outcome
Protamines drug effects
Scrotum
Semen Analysis
Sperm Count
Sperm Motility drug effects
Zinc Sulfate administration & dosage
Heat Stress Disorders physiopathology
Hot Temperature adverse effects
Infertility, Male etiology
Spermatozoa drug effects
Zinc Sulfate therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1439-0272
- Volume :
- 41
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Andrologia
- Publication Type :
- Academic Journal
- Accession number :
- 19601933
- Full Text :
- https://doi.org/10.1111/j.1439-0272.2009.00920.x