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Beta endovascular brachytherapy using CO2-filled centering catheter for treatment of recurrent superficial femoropopliteal artery disease.
- Source :
-
Cardiovascular revascularization medicine : including molecular interventions [Cardiovasc Revasc Med] 2009 Jul-Sep; Vol. 10 (3), pp. 162-5. - Publication Year :
- 2009
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Abstract
- Background: Recurrent disease (restenosis) after endovascular treatment of the superficial femoral artery (SFA) remains a major problem. We evaluated the efficacy of beta-endovascular brachytherapy using the CORONA centering catheter in patients with SFA restenosis in a single-arm Phase II trial.<br />Methods and Results: A total of 28 patients (mean age 70 years; 16 female, 12 male) with recurrent SFA stenosis were treated, and in-stent restenosis was present in 17 patients (61%). Brachytherapy was performed with strontium-90 beta source using a 7-French CO(2)-filled one-segment centering catheter. New stents had to be applied in two cases. Mean interventional length was 129 mm (range 20-240 mm). A dose of 14 Gy in vessel radius (postinterventional) plus 2 mm was applied in 24 patients and 18.4 Gy in four patients. Treatment time was 7 min 32 s per radiation segment. No major adverse events occurred. Patients were followed by ankle-brachial index and duplex sonography for a median of 42 months. Cumulative restenosis rates at 1, 2, and 3 years were 9%, 28%, and 40%, respectively. Target vessel revascularization was performed in seven cases (25%).<br />Conclusions: In comparison to literature data, the treatment of SFA restenosis with beta brachytherapy may improve long-term patency.
- Subjects :
- Aged
Carbon Dioxide
Constriction, Pathologic
Equipment Design
Female
Humans
Kaplan-Meier Estimate
Male
Peripheral Vascular Diseases physiopathology
Peripheral Vascular Diseases radiotherapy
Platelet Aggregation Inhibitors therapeutic use
Prospective Studies
Radiation Dosage
Recurrence
Stents
Time Factors
Treatment Outcome
Vascular Patency
Angioplasty, Balloon instrumentation
Brachytherapy instrumentation
Catheterization, Peripheral instrumentation
Femoral Artery physiopathology
Peripheral Vascular Diseases therapy
Popliteal Artery physiopathology
Strontium Radioisotopes therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1878-0938
- Volume :
- 10
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Cardiovascular revascularization medicine : including molecular interventions
- Publication Type :
- Academic Journal
- Accession number :
- 19595397
- Full Text :
- https://doi.org/10.1016/j.carrev.2009.02.005