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Cyclin A is redundant in fibroblasts but essential in hematopoietic and embryonic stem cells.
- Source :
-
Cell [Cell] 2009 Jul 23; Vol. 138 (2), pp. 352-65. Date of Electronic Publication: 2009 Jul 09. - Publication Year :
- 2009
-
Abstract
- Cyclins are regulatory subunits of cyclin-dependent kinases. Cyclin A, the first cyclin ever cloned, is thought to be an essential component of the cell-cycle engine. Mammalian cells encode two A-type cyclins, testis-specific cyclin A1 and ubiquitously expressed cyclin A2. Here, we tested the requirement for cyclin A function using conditional knockout mice lacking both A-type cyclins. We found that acute ablation of cyclin A in fibroblasts did not affect cell proliferation, but led to prolonged expression of another cyclin, cyclin E, across the cell cycle. However, combined ablation of all A- and E-type cyclins extinguished cell division. In contrast, cyclin A function was essential for cell-cycle progression of hematopoietic and embryonic stem cells. Expression of cyclin A is particularly high in these compartments, which might render stem cells dependent on cyclin A, whereas in fibroblasts cyclins A and E play redundant roles in cell proliferation.
Details
- Language :
- English
- ISSN :
- 1097-4172
- Volume :
- 138
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Cell
- Publication Type :
- Academic Journal
- Accession number :
- 19592082
- Full Text :
- https://doi.org/10.1016/j.cell.2009.04.062