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Exercise attenuates the clinical, synaptic and dendritic abnormalities of experimental autoimmune encephalomyelitis.
- Source :
-
Neurobiology of disease [Neurobiol Dis] 2009 Oct; Vol. 36 (1), pp. 51-9. Date of Electronic Publication: 2009 Jul 08. - Publication Year :
- 2009
-
Abstract
- Voluntary exercise is beneficial in models of primarily neurodegenerative disorders. Whether exercise also affects inflammatory neurodegeneration is unknown. In the present study, we evaluated the clinical, synaptic and neuropathological effects of voluntary wheel running in mice with myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis. Exercising EAE mice exhibited less severe neurological deficits compared to control EAE animals. The sensitivity of striatal GABA synapses to the stimulation of cannabinoid CB1 receptors was dramatically downregulated following EAE induction, and was rescued by exercise in EAE mice with access to a running wheel. Finally, we found that exercise was able to contrast dendritic spine loss induced by EAE in striatal neurons, although the degree of inflammatory response was similar in the two experimental groups. Our work suggests that life style and experiences can impact the clinical course of inflammatory neurodegenerative diseases by affecting their synaptic bases.
- Subjects :
- Animals
Antigens, CD metabolism
Corpus Striatum pathology
Dendrites pathology
Dendrites ultrastructure
Disease Models, Animal
Dronabinol analogs & derivatives
Dronabinol pharmacology
Encephalomyelitis, Autoimmune, Experimental chemically induced
Encephalomyelitis, Autoimmune, Experimental complications
Female
Glutamic Acid metabolism
Glutamic Acid pharmacology
Glycoproteins
In Vitro Techniques
Mice
Mice, Inbred C57BL
Movement Disorders etiology
Myelin-Oligodendrocyte Glycoprotein
Neurons physiology
Neuroprotective Agents pharmacology
Patch-Clamp Techniques methods
Peptide Fragments
Silver Staining methods
Statistics, Nonparametric
Synapses ultrastructure
Synaptic Potentials drug effects
Synaptic Potentials physiology
Dendrites physiology
Encephalomyelitis, Autoimmune, Experimental pathology
Encephalomyelitis, Autoimmune, Experimental rehabilitation
Neurons pathology
Physical Conditioning, Animal
Synapses physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1095-953X
- Volume :
- 36
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Neurobiology of disease
- Publication Type :
- Academic Journal
- Accession number :
- 19591937
- Full Text :
- https://doi.org/10.1016/j.nbd.2009.06.013