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CARET, the beta-carotene and retinol efficacy trial to prevent lung cancer in asbestos-exposed workers and in smokers.
- Source :
-
Anti-cancer drugs [Anticancer Drugs] 1991 Feb; Vol. 2 (1), pp. 79-86. - Publication Year :
- 1991
-
Abstract
- CARET is a two-armed, double-blind, randomized chemo-prevention trial to test the hypothesis that oral administration of beta-carotene 30 mg/day plus retinyl palmitate 25,000 IU/day will decrease the incidence of lung cancer in high-risk populations: heavy smokers and asbestos-exposed workers who have smoked. The agents combine anti-oxidant and nuclear tumor suppressor mechanisms. Fastidious monitoring for possible side effects is facilitated by inclusion of a Vanguard population. As of 31 December 1990, 6,105 participants of the 18,000 needed have been randomized in the trial. Efficacy results are expected in 1999.
- Subjects :
- Aged
Double-Blind Method
Drug Therapy, Combination
Female
Follow-Up Studies
Humans
Lung Neoplasms etiology
Male
Middle Aged
Occupational Exposure
beta Carotene
Asbestos adverse effects
Carotenoids therapeutic use
Lung Neoplasms prevention & control
Smoking adverse effects
Vitamin A therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0959-4973
- Volume :
- 2
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Anti-cancer drugs
- Publication Type :
- Academic Journal
- Accession number :
- 1958856
- Full Text :
- https://doi.org/10.1097/00001813-199102000-00011