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Molecular mechanism of inhibition of the human protein complex Hsp90-Cdc37, a kinome chaperone-cochaperone, by triterpene celastrol.
- Source :
-
Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2009; Vol. 48 (32), pp. 5853-5. - Publication Year :
- 2009
- Subjects :
- Binding Sites
Cell Cycle Proteins antagonists & inhibitors
Chaperonins antagonists & inhibitors
HSP90 Heat-Shock Proteins antagonists & inhibitors
Humans
Pentacyclic Triterpenes
Protein Folding
Triterpenes pharmacology
Cell Cycle Proteins metabolism
Chaperonins metabolism
HSP90 Heat-Shock Proteins metabolism
Triterpenes chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1521-3773
- Volume :
- 48
- Issue :
- 32
- Database :
- MEDLINE
- Journal :
- Angewandte Chemie (International ed. in English)
- Publication Type :
- Academic Journal
- Accession number :
- 19585625
- Full Text :
- https://doi.org/10.1002/anie.200900929