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Interleukin-1 and tumor necrosis factor-alpha: novel targets for immunotherapy in Eales disease.
- Source :
-
Ocular immunology and inflammation [Ocul Immunol Inflamm] 2009 May-Jun; Vol. 17 (3), pp. 201-6. - Publication Year :
- 2009
-
Abstract
- Background: Eales disease is an idiopathic obliterative vasculopathy that primarily affects the peripheral retina of young adults. The authors evaluated interleukin 1 beta (IL-1beta), interleukin-6 (IL-6), Interleukin-10 (IL-10), and tumor necrosis factor-alpha (TNF-alpha) in the serum of patients with Eales disease stages for the first time.<br />Methods: The study group consisted of 45 consecutive patients of Eales disease [inflammatory stage (n = 15) and proliferative stage (n = 30)] and 28 healthy controls. Immunoassays for the quantification of the levels of four cytokines including IL-1beta, IL-6, IL-10, and TNF-alpha in the serum samples were performed using ELISA kits.<br />Results: IL-1beta, IL-6, IL-10, and TNF-alpha levels were found to be increased significantly in the inflammatory stage of Eales disease as compared to controls (p < .001). IL-1beta levels decreased significantly during the proliferative stage of the disease as compared to the inflammatory stage (p = .03). TNF-alpha levels increased significantly during the proliferative stage as compared to the inflammatory stage (p = .02).<br />Conclusions: Raised levels of IL-1beta and TNF-alpha were observed in the inflammatory stage and persisted in the proliferative stage of the disease. The IL-1 system and TNF-alpha represent novel target for immunotherapy for controlling inflammatory activity and/or the associated long-term sequelae related to angiogenesis in Eales disease.
- Subjects :
- Adult
Enzyme-Linked Immunosorbent Assay
Humans
Interleukin-10 blood
Interleukin-6 blood
Male
Recurrence
Retinal Hemorrhage physiopathology
Retinal Hemorrhage therapy
Retinal Vasculitis physiopathology
Retinal Vasculitis therapy
Vitreous Hemorrhage blood
Vitreous Hemorrhage physiopathology
Vitreous Hemorrhage therapy
Immunotherapy
Interleukin-1beta blood
Retinal Hemorrhage blood
Retinal Vasculitis blood
Tumor Necrosis Factor-alpha blood
Subjects
Details
- Language :
- English
- ISSN :
- 1744-5078
- Volume :
- 17
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Ocular immunology and inflammation
- Publication Type :
- Academic Journal
- Accession number :
- 19585364
- Full Text :
- https://doi.org/10.1080/09273940902731015