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Nonalcoholic fatty liver is not associated with carotid intima-media thickness in type 2 diabetic patients.
- Source :
-
The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2009 Oct; Vol. 94 (10), pp. 4103-6. Date of Electronic Publication: 2009 Jul 07. - Publication Year :
- 2009
-
Abstract
- Objective: Nonalcoholic fatty liver disease (NAFLD) is commonly associated with obesity, metabolic syndrome, and type 2 diabetes. Several studies suggest that NAFLD is independently associated with an increased risk of cardiovascular disease in nondiabetic subjects. In type 2 diabetic subjects, the link between fatty liver and atherosclerosis is less clear. In this study, we set out to determine, whether fatty liver content, evaluated using 1H-magnetic resonance spectroscopy, a very precise imaging technique, was associated with atherosclerosis in people with type 2 diabetes.<br />Research Design and Methods: A total of 101 patients with type 2 diabetes mellitus were included in this study. Liver fat (1H-magnetic resonance spectroscopy) and carotid intima media thickness (IMT) were measured.<br />Results: Sixty-one (60.3%) patients had steatosis (hepatic triglyceride content greater than 5.5%). Liver fat content was correlated with fasting serum triglycerides (r = 0.22; P = 0.02) and alanine aminotransferase (r = 0.42; P = 0.0001). Sixty-eight percent of subjects with severe steatosis (hepatic triglyceride content greater than 15%) had aspartate aminotransferase in the normal range. Age was strongly correlated with IMT (r = 0.37; P = 0.0002). Steatosis did not correlate with IMT (r = -0.03; P = 0.75). There was no significant difference between the two groups (with and without hepatic steatosis) for IMT values.<br />Conclusions: this study suggests that in people with type 2 diabetes, fatty liver is not associated with cardiovascular disease. In a diabetic population, it seems that fatty liver is not a determinant factor associated with carotid IMT.
- Subjects :
- Aged
Alanine Transaminase blood
Atherosclerosis complications
Biomarkers blood
Diabetes Mellitus, Type 2 metabolism
Fatty Liver complications
Fatty Liver metabolism
Female
Humans
Liver metabolism
Liver pathology
Male
Middle Aged
Prospective Studies
Protons
Triglycerides blood
Atherosclerosis pathology
Diabetes Mellitus, Type 2 complications
Diabetes Mellitus, Type 2 pathology
Fatty Liver pathology
Magnetic Resonance Spectroscopy methods
Tunica Intima pathology
Tunica Media pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1945-7197
- Volume :
- 94
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- The Journal of clinical endocrinology and metabolism
- Publication Type :
- Academic Journal
- Accession number :
- 19584186
- Full Text :
- https://doi.org/10.1210/jc.2009-0541