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Patterns of hematologic malignancies and solid tumors among 37,838 first-degree relatives of 13,896 patients with multiple myeloma in Sweden.
- Source :
-
International journal of cancer [Int J Cancer] 2009 Nov 01; Vol. 125 (9), pp. 2147-50. - Publication Year :
- 2009
-
Abstract
- There are emerging data to suggest a role for genetic factors in the pathogenesis of multiple myeloma (MM). Based on small numbers, certain solid tumors have been reported to occur more frequently among blood relatives of patients with MM. Using population-based data, we assessed risks for hematologic malignancies, monoclonal gammopathy of undetermined significance (MGUS), and solid tumors among first-degree relatives of patients with MM. We included 13,896 patients with MM and 54,365 matched controls. Also we identified first-degree relatives of patients with MM (n = 37,838) and controls (n = 151,068). Using a marginal survival model, we estimated relative risks (RRs) and 95% confidence intervals (CIs) for hematologic and solid tumors among family members of patients with MM and controls as measures of familial aggregation. Compared with relatives of controls, relatives of patients with MM had an increased risk of developing MM (RR = 2.1; 95% CI 1.6-2.9), MGUS (2.1; 1.5-3.1), acute lymphoblastic leukemia (ALL) (2.1; 1.0-4.2), any solid tumor (1.1; 1.0-1.1) and bladder cancer (1.3; 1.0-1.5). No significantly increased risk was found for other hematologic or solid malignancies. Our findings support a role for a shared susceptibility (genetic, environmental or both) that predisposes to MM, MGUS, ALL and bladder cancer.<br /> ((c) 2009 UICC.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Case-Control Studies
Female
Hematologic Neoplasms epidemiology
Humans
Male
Middle Aged
Neoplasms epidemiology
Paraproteinemias epidemiology
Paraproteinemias genetics
Precursor Cell Lymphoblastic Leukemia-Lymphoma genetics
Sweden epidemiology
Urinary Bladder Neoplasms genetics
Family
Hematologic Neoplasms genetics
Multiple Myeloma genetics
Neoplasms genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1097-0215
- Volume :
- 125
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- International journal of cancer
- Publication Type :
- Academic Journal
- Accession number :
- 19582882
- Full Text :
- https://doi.org/10.1002/ijc.24514