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Nutritional support for head and neck cancer patients receiving radiotherapy: a systematic review.

Authors :
Garg S
Yoo J
Winquist E
Source :
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer [Support Care Cancer] 2010 Jun; Vol. 18 (6), pp. 667-77. Date of Electronic Publication: 2009 Jul 07.
Publication Year :
2010

Abstract

Purpose: Squamous cell carcinoma of the head and neck (HNSCC) is associated with weight loss before, during, and after treatment with radiotherapy (RT). This systematic review addressed the question "Which interventions aimed at optimizing nutrition are of benefit to HNSCC patients receiving RT?"<br />Methods: Randomized controlled trials (RCTs) studying interventions directed at nutritional support of adult patients with HNSCC receiving RT with or without chemotherapy were eligible. RCTs studying prophylaxis of acute mucositis, perioperative nutrition, or palliative and non-HNSCC populations were excluded. A comprehensive literature search was done and meta-analyses planned.<br />Results: Ten unique RCTs were identified (n = 585). All randomized less than 50 patients per trial arm. Five trials studied dietary counseling and/or nutritional supplements, four studied drug interventions, and one studied prophylactic enteral tube feeding. Nutritional status appeared to be maintained or improved with dietary counseling, megestrol acetate, and prophylactic enteral tube feeding.<br />Conclusions: Data from RCTs supporting the use of interventions to optimize nutrition in HNSCC patients receiving RT are limited in both quantity and quality. Potentially effective interventions have not been tested comparatively or in combination, and few patients receiving chemoradiotherapy were studied. Further research in this area is a priority.

Details

Language :
English
ISSN :
1433-7339
Volume :
18
Issue :
6
Database :
MEDLINE
Journal :
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
Publication Type :
Academic Journal
Accession number :
19582484
Full Text :
https://doi.org/10.1007/s00520-009-0686-3