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Antibodies against small molecules.

Authors :
Clementi ME
Marini S
Condò SG
Giardina B
Source :
Annali dell'Istituto superiore di sanita [Ann Ist Super Sanita] 1991; Vol. 27 (1), pp. 139-43.
Publication Year :
1991

Abstract

Compounds with low molecular weight (haptens) are not usually immunogenic. Thus, an hapten should be conjugated with a carrier protein therefore immunizing an animal, in order to induce a strong immune response and in turn obtain large amount of antibodies. Suitable macromolecules are usually albumins, thyroglobulins, haemocyanins and polylysine. The production of specific antibodies against haptens is important both for assays of hormones and drugs in biological fluids or for therapeutic applications in tumour therapy. Approaches in choice of both carrier protein and conjugation methods will be described.

Details

Language :
English
ISSN :
0021-2571
Volume :
27
Issue :
1
Database :
MEDLINE
Journal :
Annali dell'Istituto superiore di sanita
Publication Type :
Academic Journal
Accession number :
1958021