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Evaluating the potential public health impact of a Staphylococcus aureus vaccine through use of population-based surveillance for invasive methicillin-resistant S. aureus disease in the United States.
- Source :
-
Vaccine [Vaccine] 2009 Aug 13; Vol. 27 (37), pp. 5061-8. Date of Electronic Publication: 2009 Jul 02. - Publication Year :
- 2009
-
Abstract
- We evaluated the potential effects of a hypothetical vaccine in preventing invasive methicillin-resistant Staphylococcus aureus (MRSA) disease in the United States. Using an active, population-based surveillance program, we estimated baseline disease rates in the United States and compared three distinct vaccination strategies which targeted adults > or =65 years of age, persons at risk for recurrent invasive infection, and patients at hospital discharge. The strategies were projected to reduce the burden of invasive MRSA disease by 12.1%, 13.9% and 17.6%, respectively; with the strategy of vaccinating both adults > or =65 years of age and all adults at hospital discharge having the greatest impact per dose. Our data suggest that availability of an effective S. aureus vaccine could result in substantial reductions in invasive MRSA disease incidence. As candidate vaccines are evaluated, these data will be important in determining the optimal vaccination strategy.
- Subjects :
- Adolescent
Adult
Aged
Cost of Illness
Disease Outbreaks prevention & control
Humans
Immunization Programs
Infection Control
Middle Aged
Sensitivity and Specificity
Staphylococcal Infections epidemiology
United States epidemiology
Young Adult
Methicillin-Resistant Staphylococcus aureus isolation & purification
Population Surveillance
Staphylococcal Infections prevention & control
Staphylococcal Vaccines immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1873-2518
- Volume :
- 27
- Issue :
- 37
- Database :
- MEDLINE
- Journal :
- Vaccine
- Publication Type :
- Academic Journal
- Accession number :
- 19576943
- Full Text :
- https://doi.org/10.1016/j.vaccine.2009.06.055