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[Lopinavir/ritonavir monotherapy as a simplification strategy in antiretroviral therapy in clinical practice].
- Source :
-
Enfermedades infecciosas y microbiologia clinica [Enferm Infecc Microbiol Clin] 2008 Dec; Vol. 26 Suppl 16, pp. 24-6. - Publication Year :
- 2008
-
Abstract
- Although guidelines for the treatment of HIV-infected patients recommend triple drug antiretroviral therapy, because of the toxicity of these regimens, the complexity of treatment and its costs, other therapeutic options are desirable. Several clinical trials have shown that lopinavir/ritonavir (LPV/r) as a simplification strategy in antiretroviral therapy in HIV-infected patients who maintain suppression of viral replication while receiving conventional treatment regimens is safe and is associated with less toxicity than that due to prolonged exposure to protease inhibitors and nucleoside analogs. The present review summarizes the main results of the various retrospective studies on LPV/r as a simplification strategy of antiretroviral therapy in daily clinical practice.
- Subjects :
- Antiretroviral Therapy, Highly Active
Drug Combinations
Drug Resistance, Viral
HIV Protease genetics
HIV Protease Inhibitors administration & dosage
HIV Protease Inhibitors adverse effects
Humans
Lopinavir
Practice Guidelines as Topic
Pyrimidinones administration & dosage
Pyrimidinones adverse effects
Retrospective Studies
Ritonavir administration & dosage
Ritonavir adverse effects
Treatment Outcome
Viral Load
Virus Replication drug effects
HIV Infections drug therapy
HIV Protease Inhibitors therapeutic use
Pyrimidinones therapeutic use
Ritonavir therapeutic use
Subjects
Details
- Language :
- Spanish; Castilian
- ISSN :
- 0213-005X
- Volume :
- 26 Suppl 16
- Database :
- MEDLINE
- Journal :
- Enfermedades infecciosas y microbiologia clinica
- Publication Type :
- Academic Journal
- Accession number :
- 19572441
- Full Text :
- https://doi.org/10.1016/s0213-005x(08)76607-2