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Profile of hippocampal volumes and stroke risk varies by neuropsychological definition of mild cognitive impairment.
- Source :
-
Journal of the International Neuropsychological Society : JINS [J Int Neuropsychol Soc] 2009 Nov; Vol. 15 (6), pp. 890-7. Date of Electronic Publication: 2009 Jul 02. - Publication Year :
- 2009
-
Abstract
- Wide-ranging conceptual and diagnostic approaches to defining mild cognitive impairment (MCI) have led to highly variable prevalence and progression rates. We sought to examine whether bilateral hippocampal volumes and cerebrovascular risk factors in individuals characterized by two different neuropsychological definitions of MCI subtypes would also differ. Participants were 65 nondemented, community-dwelling, older adults, ages 62-91 years, drawn from a larger group of individuals enrolled in a longitudinal study of normal aging. A comprehensive neuropsychological definition of MCI that required the presence of more than one impaired score in a cognitive domain resulted in expected anatomical results; hippocampal volumes were significantly smaller in the aMCI group as compared to cognitively normal or nonamnestic MCI participants. However, a typical definitional scheme for classifying MCI based only on the presence of one impaired score within a cognitive domain did not result in hippocampal differences between groups. Global stroke risk factors did not differ between the two definitional schemes, although the relationship between stroke risk variables and neuropsychological performance did vary by diagnostic approach. The comprehensive approach demonstrated associations between stroke risk and cognition, whereas the typical approach did not. Use of more sophisticated clinical decision-making and diagnostic approaches that incorporate comprehensive neuropsychological assessment techniques is supported by this convergence of neuropsychological, neuropathological, and stroke risk findings.
- Subjects :
- Aged
Aged, 80 and over
Female
Geriatric Assessment
Humans
Longitudinal Studies
Magnetic Resonance Imaging methods
Male
Middle Aged
Multivariate Analysis
Neuropsychological Tests
Psychiatric Status Rating Scales
Residence Characteristics
Risk Factors
Cardiovascular Diseases complications
Cognition Disorders etiology
Cognition Disorders pathology
Hippocampus pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1469-7661
- Volume :
- 15
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of the International Neuropsychological Society : JINS
- Publication Type :
- Academic Journal
- Accession number :
- 19570306
- Full Text :
- https://doi.org/10.1017/S1355617709090638