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Biaryl polyamides as a new class of DNA quadruplex-binding ligands.
- Source :
-
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2009 Jul 21 (27), pp. 4097-9. Date of Electronic Publication: 2009 Jun 05. - Publication Year :
- 2009
-
Abstract
- We report a novel class of biaryl polyamides highly selective for G-quadruplex DNA, and with significant cytotoxicity in several cancer cell lines; they form planar U-shaped structures that match the surface area dimensions of a terminal G-quartet in quadruplex structures rather than the grooves of duplex DNA.
- Subjects :
- Antineoplastic Agents chemical synthesis
Antineoplastic Agents chemistry
Cell Line, Tumor
Cell Proliferation drug effects
Circular Dichroism
Fibroblasts drug effects
Fibroblasts metabolism
Humans
Inhibitory Concentration 50
Ligands
Nylons chemical synthesis
Nylons chemistry
Antineoplastic Agents pharmacology
G-Quadruplexes drug effects
Nylons pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1359-7345
- Issue :
- 27
- Database :
- MEDLINE
- Journal :
- Chemical communications (Cambridge, England)
- Publication Type :
- Academic Journal
- Accession number :
- 19568645
- Full Text :
- https://doi.org/10.1039/b902359c