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[Pathogenesis of arterial hypertension in patients with primary hypothyroidism].
- Source :
-
Klinicheskaia meditsina [Klin Med (Mosk)] 2009; Vol. 87 (5), pp. 30-2. - Publication Year :
- 2009
-
Abstract
- The aim of this work was to study the role of hypovolemia on pathogenesis of arterial hypertension (AH) in patients with primary hypothyroidism (PH) and specification of indirect signs indicative of increased circulating blood volume. 217patients with PH and AH (mean age 53.3 yr) received substitution therapy with sodium levothyroxin and standard hypotensive therapy with ACE inhibitors. All the patients allocated to 3 groups were examined by 24 hour Holter monitoring and measurement of serum TSH and free T4. Group 1 (n = 74) were patients with compensated PH, group 2 (n = 57) comprised patients with subclinical hypothyroidism, group 3 (n = 86) were patients with decompensated hypothyroidism. The latter group was dominated by non-dippers, the patients showed elevated systolic and diastolic AD, its small reduction and high variability at night time. These clinical and functional signs are supposed to reflect hypovolemia in patients with PH and concomitant AH.
- Subjects :
- Angiotensin-Converting Enzyme Inhibitors therapeutic use
Electrocardiography, Ambulatory
Female
Follow-Up Studies
Humans
Hypertension drug therapy
Hypertension physiopathology
Hypothyroidism blood
Hypothyroidism physiopathology
Hypovolemia complications
Hypovolemia physiopathology
Male
Middle Aged
Thyrotropin blood
Blood Pressure physiology
Hypertension etiology
Hypothyroidism complications
Subjects
Details
- Language :
- Russian
- ISSN :
- 0023-2149
- Volume :
- 87
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Klinicheskaia meditsina
- Publication Type :
- Academic Journal
- Accession number :
- 19565824