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DNA replication initiation.
- Source :
-
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2009; Vol. 521, pp. 3-17. - Publication Year :
- 2009
-
Abstract
- DNA replication is fundamental to cellular life on earth, and replication initiation provides the primary point of control over this process. Replication initiation in all organisms involves the interaction of initiator proteins with one or more origins of replication in the DNA, with subsequent regulated assembly of two replisome complexes at each origin, melting of the DNA, and primed initiation of DNA synthesis on leading and lagging strands. Archaea and Eukarya share homologous systems for DNA replication initiation, but differ in the complexity of these; Bacteria appear to have analogous, rather than homologous, mechanisms for replication initiation. This chapter provides an overview of current knowledge of initiation of chromosomal DNA replication in the three domains of life.
- Subjects :
- Animals
Archaea genetics
Archaea metabolism
Bacteria genetics
Bacteria metabolism
DNA Replication Timing
DNA, Archaeal biosynthesis
DNA, Archaeal genetics
DNA, Bacterial biosynthesis
DNA, Bacterial genetics
DNA, Fungal biosynthesis
DNA, Fungal genetics
Humans
Models, Biological
Replication Origin
Saccharomyces cerevisiae genetics
Saccharomyces cerevisiae metabolism
Schizosaccharomyces genetics
Schizosaccharomyces metabolism
DNA Replication genetics
DNA Replication physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1064-3745
- Volume :
- 521
- Database :
- MEDLINE
- Journal :
- Methods in molecular biology (Clifton, N.J.)
- Publication Type :
- Academic Journal
- Accession number :
- 19563098
- Full Text :
- https://doi.org/10.1007/978-1-60327-815-7_1