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Immunoregulatory Cordyceps sinensis increases regulatory T cells to Th17 cell ratio and delays diabetes in NOD mice.
- Source :
-
International immunopharmacology [Int Immunopharmacol] 2009 May; Vol. 9 (5), pp. 582-6. - Publication Year :
- 2009
-
Abstract
- Cordyceps sinensis (CS) is a parasitic fungus, and it has been used widely in traditional Chinese medicines (TCM) for centuries. Many studies have shown that CS has immunoregulatory activity in many disease models, but the underlying mechanism remains elusive. We studied whether CS could suppress the onset of diabetes by altering T lymphocyte subsets in non-obese diabetic (NOD) mice. We found that the onset of type 1 diabetes in NOD mice was associated with an imbalance of CD4(+)CD25(+)FoxP3(+) regulatory T (Treg) cells and IL-17 producing Th17 cells. Oral administration of CS resulted in reduction in the overall incidence of diabetes, and this was due to an increase in the ratio of Treg cells to Th17 in the spleen and pancreatic lymph nodes (PLNs). Taken together, these data imply that CS is able to modulate Treg to Th17 cell ratio in vivo, thus contributing to the inhibition of diabetes.
- Subjects :
- Animals
CD4 Antigens
Cell Movement
Diabetes Mellitus, Type 1 pathology
Diabetes Mellitus, Type 1 physiopathology
Female
Forkhead Transcription Factors genetics
Forkhead Transcription Factors immunology
Interleukin-17 genetics
Interleukin-17 immunology
Interleukin-2 Receptor alpha Subunit
Mice
Mice, Inbred BALB C
Mice, Inbred NOD
T-Lymphocytes, Helper-Inducer immunology
T-Lymphocytes, Helper-Inducer pathology
T-Lymphocytes, Regulatory immunology
T-Lymphocytes, Regulatory pathology
Cordyceps
Diabetes Mellitus, Type 1 drug therapy
Drugs, Chinese Herbal therapeutic use
Forkhead Transcription Factors metabolism
Interleukin-17 metabolism
T-Lymphocytes, Helper-Inducer metabolism
T-Lymphocytes, Regulatory metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1878-1705
- Volume :
- 9
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- International immunopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 19557879
- Full Text :
- https://doi.org/10.1016/j.intimp.2009.01.030