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The persistence of t(14;18)-bearing cells in lymph nodes of patients with follicular lymphoma in complete remission: the evidence for 'a lymphoma stem cell'.
- Source :
-
Leukemia & lymphoma [Leuk Lymphoma] 2009 Jul; Vol. 50 (7), pp. 1102-9. - Publication Year :
- 2009
-
Abstract
- Monitoring of t(14;18) in blood or bone marrow in follicular lymphoma (FL) remains controversial. We attempted to monitor t(14;18) in lymph nodes by ultrasound-guided fine needle aspirations (UG-FNA). First, we confirmed t(14;18) in 27/31 UG-FNAs of lymph nodes with fluorescent in situ hybridisation (FISH) and/or polymerase chain reaction (PCR) in patients with advanced disease. In complete (CR) and molecular remission, there were repeated 18 UG-FNAs in 17 patients. Five of 18 UG-FNA were technically unsuccessful and 6/18 samples contained fibrosis. Despite that, these patients had a better prognosis. In 7/7 aspirations in six patients, t(14;18) was detected. Three patients are still in CR, even one of them remains in long lasting remission despite two consecutive evidences of t(14;18) in UG-FNA. Another three of these patients relapsed a few months after UG-FNA. This study is proof of the principle of the detection of residual t(14;18) bearing cells in previously involved lymph nodes despite patients being in remission.
- Subjects :
- Adult
Aged
Female
Humans
In Situ Hybridization, Fluorescence
Lymph Nodes pathology
Male
Middle Aged
Prognosis
Proto-Oncogene Proteins c-bcl-2 metabolism
Remission Induction
Treatment Outcome
Chromosomes, Human, Pair 14
Chromosomes, Human, Pair 18
Lymphoma, Follicular genetics
Lymphoma, Follicular therapy
Neoplastic Stem Cells cytology
Subjects
Details
- Language :
- English
- ISSN :
- 1029-2403
- Volume :
- 50
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Leukemia & lymphoma
- Publication Type :
- Academic Journal
- Accession number :
- 19557630
- Full Text :
- https://doi.org/10.1080/10428190902927005