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Serum and pleural fluid procalcitonin in predicting bacterial infection in patients with parapneumonic effusion.
- Source :
-
Journal of Korean medical science [J Korean Med Sci] 2009 Jun; Vol. 24 (3), pp. 398-402. Date of Electronic Publication: 2009 Jun 12. - Publication Year :
- 2009
-
Abstract
- This study evaluated the value of procalcitonin (PCT) levels in pleural effusion to differentiate the etiology of parapneumonic effusion (PPE). Forty-one consecutive PPE patients were enrolled and were divided into bacterial and non-bacterial PPE. Blood and pleural effusion samples were collected for PCT measurement on admission and analyzed for diagnostic evaluation. PCT of pleural fluid was significantly increased in the bacterial PPE group (0.24 ng/mL) compared to the non-bacterial PPE group (0.09 ng/mL), but there was no significant difference for serum PCT. A PCT concentration of pleural fluid >0.174 ng/mL (best cut-off value) was considered positive for a diagnosis of bacterial PPE (sensitivity, 80%; specificity, 76%; AUC, 0.84). Pleural effusion PCT in the bacterial PPE is significantly different from those of the non-bacterial PPE and control groups, so the diagnostic use of PCT still warrants further investigation.
- Subjects :
- Aged
Calcitonin blood
Calcitonin Gene-Related Peptide
Diagnosis, Differential
Female
Humans
Male
Middle Aged
Predictive Value of Tests
Protein Precursors blood
ROC Curve
Bacterial Infections diagnosis
Calcitonin analysis
Pleural Effusion diagnosis
Pneumonia diagnosis
Protein Precursors analysis
Subjects
Details
- Language :
- English
- ISSN :
- 1598-6357
- Volume :
- 24
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of Korean medical science
- Publication Type :
- Academic Journal
- Accession number :
- 19543500
- Full Text :
- https://doi.org/10.3346/jkms.2009.24.3.398