Back to Search
Start Over
Investigation of aminopyridiopyrazinones as PDE5 inhibitors: Evaluation of modifications to the central ring system.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2009 Aug 01; Vol. 19 (15), pp. 4092-6. Date of Electronic Publication: 2009 Jun 06. - Publication Year :
- 2009
-
Abstract
- Efforts to improve the potency and physical properties of the aminopyridiopyrazinone class of PDE5 inhibitors through modification of the core ring system are described. Five new ring systems are evaluated and features that impart improved potency and improved solubility are delineated.
- Subjects :
- Administration, Oral
Aminopyridines pharmacology
Animals
Chemistry, Pharmaceutical methods
Cyclic GMP chemistry
Cyclic Nucleotide Phosphodiesterases, Type 5 chemistry
Drug Design
Humans
Hydrogen-Ion Concentration
Hypertension drug therapy
Microsomes drug effects
Models, Chemical
Phosphodiesterase Inhibitors pharmacology
Pyrazines pharmacology
Rats
Rats, Sprague-Dawley
Solubility
Aminopyridines chemical synthesis
Phosphodiesterase 5 Inhibitors
Phosphodiesterase Inhibitors chemical synthesis
Pyrazines chemical synthesis
Subjects
Details
- Language :
- English
- ISSN :
- 1464-3405
- Volume :
- 19
- Issue :
- 15
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 19539468
- Full Text :
- https://doi.org/10.1016/j.bmcl.2009.06.004