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First trial of spatial and temporal fractionations of the delivered dose using synchrotron microbeam radiation therapy.
- Source :
-
Journal of synchrotron radiation [J Synchrotron Radiat] 2009 Jul; Vol. 16 (Pt 4), pp. 587-90. Date of Electronic Publication: 2009 May 12. - Publication Year :
- 2009
-
Abstract
- The technical feasibility of temporal and spatial fractionations of the radiation dose has been evaluated using synchrotron microbeam radiation therapy for brain tumors in rats. A significant increase in lifespan (216%, p < 0.0001) resulted when three fractions of microbeam irradiation were applied to the tumor through three different ports, orthogonal to each other, at 24 h intervals. However, there were no long-term survivors, and immunohistological studies revealed that 9 L tumors were not entirely ablated.
Details
- Language :
- English
- ISSN :
- 1600-5775
- Volume :
- 16
- Issue :
- Pt 4
- Database :
- MEDLINE
- Journal :
- Journal of synchrotron radiation
- Publication Type :
- Academic Journal
- Accession number :
- 19535875
- Full Text :
- https://doi.org/10.1107/S0909049509012485