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Pathological influence of obesity on renal structural changes in chronic kidney disease.
- Source :
-
Clinical and experimental nephrology [Clin Exp Nephrol] 2009 Aug; Vol. 13 (4), pp. 332-340. Date of Electronic Publication: 2009 Apr 29. - Publication Year :
- 2009
-
Abstract
- Background: Role of obesity in renal pathological and structural changes remains poorly investigated, and this study was designed to examine the pathological effects of obesity on renal structural components in patients with chronic kidney diseases (CKD).<br />Methods: The study subjects were obese (body mass index, BMI > or = 25 kg/m2) patients with nonglomerulonephritis (non-GN, n = 26), IgA nephropathy (IgAN, n = 19), benign nephrosclerosis (BNS, n = 15), and thin basement membrane disease (TMD, n = 6), and 65 nonobese controls (n = 20, 20, 10, and 15, respectively). Patients were evaluated for glomerular lesions (mesangial proliferation and focal segmental/global glomerulosclerosis), glomerular size, and thickness of glomerular basement membrane (GBM).<br />Results: Urinary protein was higher in obese non-GN, IgAN, and BNS groups than in the respective controls. Focal segmental glomerulosclerosis (FSGS) lesions were noted in all obesity groups. The glomeruli were larger in size in obese than in nonobese patients of the non-GN and IgAN groups. The glomeruli of nonobese TMD and BNS patients were significantly larger in size than those of nonobese non-GN patients. GBM were thicker in obese than in nonobese patients irrespective of types of glomerular diseases, but only significantly so in non-GN and BNS groups.<br />Conclusion: In non-GN, IgAN, and BNS, obesity worsens proteinuria and is associated with structural changes such as glomerulomegaly and GBM thickening, similar to changes observed in obesity-related nephropathy. Obesity seems to worsen the renopathological state in CKD.
- Subjects :
- Adolescent
Adult
Body Mass Index
Case-Control Studies
Chronic Disease
Disease Progression
Female
Glomerular Basement Membrane pathology
Glomerulonephritis, IGA complications
Glomerulonephritis, IGA pathology
Humans
Kidney Diseases pathology
Male
Nephrosclerosis complications
Nephrosclerosis pathology
Obesity pathology
Proteinuria etiology
Proteinuria pathology
Risk Factors
Severity of Illness Index
Young Adult
Kidney Diseases complications
Kidney Glomerulus pathology
Obesity complications
Subjects
Details
- Language :
- English
- ISSN :
- 1437-7799
- Volume :
- 13
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Clinical and experimental nephrology
- Publication Type :
- Academic Journal
- Accession number :
- 19533267
- Full Text :
- https://doi.org/10.1007/s10157-009-0169-3