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Novel peptide therapeutics for treatment of infections.

Authors :
Oyston PCF
Fox MA
Richards SJ
Clark GC
Source :
Journal of medical microbiology [J Med Microbiol] 2009 Aug; Vol. 58 (Pt 8), pp. 977-987. Date of Electronic Publication: 2009 Jun 15.
Publication Year :
2009

Abstract

As antibiotic resistance increases worldwide, there is an increasing pressure to develop novel classes of antimicrobial compounds to fight infectious disease. Peptide therapeutics represent a novel class of therapeutic agents. Some, such as cationic antimicrobial peptides and peptidoglycan recognition proteins, have been identified from studies of innate immune effector mechanisms, while others are completely novel compounds generated in biological systems. Currently, only selected cationic antimicrobial peptides have been licensed, and only for topical applications. However, research using new approaches to identify novel antimicrobial peptide therapeutics, and new approaches to delivery and improving stability, will result in an increased range of peptide therapeutics available in the clinic for broader applications.

Details

Language :
English
ISSN :
0022-2615
Volume :
58
Issue :
Pt 8
Database :
MEDLINE
Journal :
Journal of medical microbiology
Publication Type :
Academic Journal
Accession number :
19528155
Full Text :
https://doi.org/10.1099/jmm.0.011122-0