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Memory and decision making in the frontal cortex during visual motion processing for smooth pursuit eye movements.
- Source :
-
Neuron [Neuron] 2009 Jun 11; Vol. 62 (5), pp. 717-32. - Publication Year :
- 2009
-
Abstract
- Cortical motor areas are thought to contribute "higher-order processing," but what that processing might include is unknown. Previous studies of the smooth pursuit-related discharge of supplementary eye field (SEF) neurons have not distinguished activity associated with the preparation for pursuit from discharge related to processing or memory of the target motion signals. Using a memory-based task designed to separate these components, we show that the SEF contains signals coding retinal image-slip-velocity, memory, and assessment of visual motion direction, the decision of whether to pursue, and the preparation for pursuit eye movements. Bilateral muscimol injection into SEF resulted in directional errors in smooth pursuit, errors of whether to pursue, and impairment of initial correct eye movements. These results suggest an important role for the SEF in memory and assessment of visual motion direction and the programming of appropriate pursuit eye movements.
- Subjects :
- Action Potentials drug effects
Action Potentials physiology
Analysis of Variance
Animals
Attention physiology
Cues
Frontal Lobe cytology
Frontal Lobe drug effects
Functional Laterality
GABA Agonists pharmacology
Macaca mulatta
Motion Perception drug effects
Muscimol pharmacology
Neurons classification
Neurons drug effects
Neurons physiology
Orientation
Photic Stimulation methods
Psychomotor Performance drug effects
Psychomotor Performance physiology
Pursuit, Smooth drug effects
Reaction Time drug effects
Reaction Time physiology
Statistics as Topic
Task Performance and Analysis
Time Factors
Video Games
Decision Making physiology
Frontal Lobe physiology
Memory physiology
Motion Perception physiology
Pursuit, Smooth physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1097-4199
- Volume :
- 62
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Neuron
- Publication Type :
- Academic Journal
- Accession number :
- 19524530
- Full Text :
- https://doi.org/10.1016/j.neuron.2009.05.010