Back to Search
Start Over
[Management of malignant phyllodes tumors of the breast: the experience of the Institut Curie].
- Source :
-
Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique [Cancer Radiother] 2009 Jul; Vol. 13 (4), pp. 305-12. Date of Electronic Publication: 2009 Jun 12. - Publication Year :
- 2009
-
Abstract
- Purpose: Given the scarcity of malignant phyllode tumours of the breast and the absence of consensus regarding their management justify the need for institutional retrospective evaluations of clinical practices.<br />Patients and Methods: Retrospective study with central pathology review of the 25 consecutive patients treated at the Institut Curie (Paris, France) between 1969 and 2006 for non metastatic malignant phyllodes tumors of the breast. The median follow-up was 65 months (7-257 months).<br />Results: Median age at diagnosis was 52 years (20-64 years). Breast surgery was conservative in five patients (20%). Surgical margins were wide (> 10mm), narrow, involved or unknown in respectively 17 (68%), three (12%), three (12%) and two (8%) patients. Median tumour size was 65 mm (12-250 mm). Adjuvant radiotherapy was delivered in seven (28%) patients (two patients, post-tumorectomy; five patients, post-mastectomy) and 13 patients (52%) received anthracycline-based adjuvant chemotherapy. Five-year overall survival rate was 91% (95% CI, 80-100%). Five patients (20%) developed distant metastases (one after chemotherapy) and three (12%) locoregional relapse (one after tumorectomy and unknown margin without radiotherapy, two after mastectomy and involved margins with radiotherapy).<br />Conclusion: Wide breast surgery (that can be conservative in selected patients) is the mainstay of the treatment of non metastatic malignant phyllodes tumors of the breast. To better determine the respective roles of adjuvant systemic treatment and radiotherapy, further clinical studies and the search for new prognostic and predictive factors remain necessary.
- Subjects :
- Adult
Cancer Care Facilities
Chemotherapy, Adjuvant
Female
France
Humans
Mastectomy methods
Middle Aged
Retrospective Studies
Survival Rate
Young Adult
Breast Neoplasms mortality
Breast Neoplasms pathology
Breast Neoplasms radiotherapy
Breast Neoplasms surgery
Phyllodes Tumor mortality
Phyllodes Tumor pathology
Phyllodes Tumor radiotherapy
Phyllodes Tumor surgery
Subjects
Details
- Language :
- French
- ISSN :
- 1769-6658
- Volume :
- 13
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique
- Publication Type :
- Academic Journal
- Accession number :
- 19524472
- Full Text :
- https://doi.org/10.1016/j.canrad.2009.05.001