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Pathology of inherited rickets in Corriedale sheep.
- Source :
-
Journal of comparative pathology [J Comp Pathol] 2009 Aug-Oct; Vol. 141 (2-3), pp. 147-55. Date of Electronic Publication: 2009 Jun 12. - Publication Year :
- 2009
-
Abstract
- A skeletal disease with features of rickets and simple autosomal recessive inheritance has been discovered in Corriedale sheep in New Zealand. The clinical signs resemble rickets in other species and include decreased growth rate, thoracic lordosis and angular limb deformities. Gross lesions include segmental thickening of physes, growth arrest lines, collapse of subchondral bone of the humeral head, thickened cortices and enthesophytes around distal limb joints. Microscopically, there is persistence of hypertrophic chondrocytes at sites of endochondral ossification, inappropriate and excessive osteoclastic resorption, microfractures and wide, unmineralized osteoid seams lining trabeculae and filling secondary osteons. This study confirms that this skeletal disease of Corriedale sheep is a newly discovered form of inherited rickets and suggests that the genetic defect may be different from inherited forms of rickets described to date in man and animals.
- Subjects :
- Animals
Bone Resorption pathology
Bone and Bones pathology
Chondrocytes pathology
Female
Fractures, Spontaneous pathology
Fractures, Spontaneous physiopathology
Humans
Hypertrophy
Lameness, Animal genetics
Lameness, Animal pathology
Lameness, Animal physiopathology
Limb Deformities, Congenital genetics
Limb Deformities, Congenital pathology
Male
Osteoclasts pathology
Rickets genetics
Rickets pathology
Sheep
Sheep Diseases pathology
Genes, Recessive
Limb Deformities, Congenital veterinary
Rickets veterinary
Sheep Diseases genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1532-3129
- Volume :
- 141
- Issue :
- 2-3
- Database :
- MEDLINE
- Journal :
- Journal of comparative pathology
- Publication Type :
- Academic Journal
- Accession number :
- 19524252
- Full Text :
- https://doi.org/10.1016/j.jcpa.2009.04.005