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Endogenous opioid peptides: multiple agonists and receptors.

Authors :
Lord JA
Waterfield AA
Hughes J
Kosterlitz HW
Source :
Nature [Nature] 1977 Jun 09; Vol. 267 (5611), pp. 495-9.
Publication Year :
1977

Abstract

Opioid peptides were assayed by inhibition of 3H-naloxone and 3H-leu-enkephalin binding in brain homogenates and by depression of contractions of the guinea pig ileum and mouse vas deferens. We conclude that the opioid peptidergic system has agonists of different characteristics which interact with more than one type of receptor.

Subjects

Subjects :
Animals
Benzomorphans analogs & derivatives
Benzomorphans metabolism
Guinea Pigs
Male
Mice
Naloxone metabolism
Narcotic Antagonists metabolism
Narcotics metabolism
Structure-Activity Relationship
Brain metabolism
Endorphins metabolism
Enkephalins metabolism
Ileum metabolism
Oligopeptides metabolism
Peptides metabolism
Receptors, Opioid metabolism
Vas Deferens metabolism

Details

Language :
English
ISSN :
0028-0836
Volume :
267
Issue :
5611
Database :
MEDLINE
Journal :
Nature
Publication Type :
Academic Journal
Accession number :
195217
Full Text :
https://doi.org/10.1038/267495a0
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