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DNA breaks as triggers for antigenic variation in African trypanosomes.

Authors :
Alsford S
Horn D
Glover L
Source :
Genome biology [Genome Biol] 2009; Vol. 10 (6), pp. 223. Date of Electronic Publication: 2009 Jun 08.
Publication Year :
2009

Abstract

The DNA repair machinery has been co-opted for antigenic variation in African trypanosomes. New work directly demonstrates that a double-strand break initiates a switch in the expressed variant surface coat.

Details

Language :
English
ISSN :
1474-760X
Volume :
10
Issue :
6
Database :
MEDLINE
Journal :
Genome biology
Publication Type :
Academic Journal
Accession number :
19519956
Full Text :
https://doi.org/10.1186/gb-2009-10-6-223