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Nanocrystalline titanium dioxide and magnesium oxide in vitro dermal absorption in human skin.
- Source :
-
Cutaneous and ocular toxicology [Cutan Ocul Toxicol] 2009; Vol. 28 (2), pp. 78-82. - Publication Year :
- 2009
-
Abstract
- The dermal absorption potential of a nanocrystalline magnesium oxide (MgO) and titanium dioxide (TiO(2)) mixture in dermatomed human skin was assessed in vitro using Bronaugh-type flow-through diffusion cells. Nanocrystalline material was applied to the skin surface at a dose rate of 50 mg/cm(2) as a dry powder, as a water suspension, and as a water/surfactant (sodium lauryl sulfate) suspension, for 8 hours. Dermal absorption of nanocrystalline MgO and TiO(2) through human skin with intact, functional stratum corneum was not detectable under the conditions of this experiment.
- Subjects :
- Administration, Topical
Adult
Diffusion Chambers, Culture
Humans
In Vitro Techniques
Magnesium Oxide administration & dosage
Magnesium Oxide blood
Magnesium Oxide chemistry
Magnesium Oxide toxicity
Microscopy, Electron, Transmission
Models, Biological
Skin metabolism
Skin ultrastructure
Titanium administration & dosage
Titanium blood
Titanium chemistry
Titanium toxicity
Magnesium Oxide pharmacokinetics
Nanoparticles
Skin drug effects
Skin Absorption
Titanium pharmacokinetics
Subjects
Details
- Language :
- English
- ISSN :
- 1556-9535
- Volume :
- 28
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Cutaneous and ocular toxicology
- Publication Type :
- Academic Journal
- Accession number :
- 19514931
- Full Text :
- https://doi.org/10.1080/15569520902914926