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[Oral insulin preparations for the regulation of the glucose level in the blood].
- Source :
-
Biomeditsinskaia khimiia [Biomed Khim] 2009 Mar-Apr; Vol. 55 (2), pp. 195-200. - Publication Year :
- 2009
-
Abstract
- Oral administration of diluted solutions of insulin results in the absorption of the hormone into bloodstream. After oral administration of diluted insulin solutions to healthy volunteers and animals with experimental diabetes insulin does not undergo hydrolytic degradation under the action of proteolytic enzymes and its absorption is sufficient to produce the hypoglycemic effect. This approach gives a chance of creating of novel strategy for diabetes treatment.
- Subjects :
- Administration, Oral
Adult
Animals
Dose-Response Relationship, Drug
Female
Humans
Male
Middle Aged
Rabbits
Rats
Rats, Wistar
Blood Glucose analysis
Diabetes Mellitus, Experimental blood
Diabetes Mellitus, Experimental drug therapy
Hypoglycemic Agents administration & dosage
Insulin administration & dosage
Subjects
Details
- Language :
- Russian
- ISSN :
- 2310-6972
- Volume :
- 55
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Biomeditsinskaia khimiia
- Publication Type :
- Academic Journal
- Accession number :
- 19507343