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Effects of theaflavins on melanin biosynthesis in mouse b16 melanoma cells.
- Source :
-
Bioscience, biotechnology, and biochemistry [Biosci Biotechnol Biochem] 2009 Jun; Vol. 73 (6), pp. 1429-31. Date of Electronic Publication: 2009 Jun 07. - Publication Year :
- 2009
-
Abstract
- In this study, we examined the effects of theaflavins, polyphenols in black tea, on alpha melanocyte-stimulating hormone (alphaMSH)-induced melanogenesis in mouse B16 melanoma cells. Among theaflavins, theaflavin-3,3'-digallate (TF-3) exhibited a potent inhibitory effect on melanogenesis. Our results indicate that the inhibitory effect of TF-3 on melanogenesis is due to suppression of tyrosinase protein and mRNA levels.
- Subjects :
- Animals
Base Sequence
Cell Line, Tumor
DNA Primers
Electrophoresis, Polyacrylamide Gel
Melanoma, Experimental enzymology
Melanoma, Experimental pathology
Mice
Monophenol Monooxygenase genetics
Monophenol Monooxygenase metabolism
RNA, Messenger genetics
Reverse Transcriptase Polymerase Chain Reaction
Biflavonoids pharmacology
Catechin pharmacology
Melanins biosynthesis
Melanoma, Experimental metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1347-6947
- Volume :
- 73
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Bioscience, biotechnology, and biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 19502752
- Full Text :
- https://doi.org/10.1271/bbb.80880