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Analysis of CD8+CD28- T-suppressor cells in living donor liver transplant recipients.
- Source :
-
Hepatobiliary & pancreatic diseases international : HBPD INT [Hepatobiliary Pancreat Dis Int] 2009 Jun; Vol. 8 (3), pp. 241-6. - Publication Year :
- 2009
-
Abstract
- Background: Human CD8+CD28- T-suppressor (Ts) cells have been considered to indicate a reduced need for immunosuppression in pediatric liver-intestine transplant recipients and recipients of deceased heart-kidney transplants. However, in adult-to-adult living donor liver transplantation (A-A LDLT) little information is available and the clinical significance is still unknown.<br />Methods: Flow cytometry was used to detect the population of CD8+CD28- Ts cells present in peripheral blood in A-A LDLT recipients (n=31), patients with end-stage liver disease (n=24) and healthy controls (n=19). Meanwhile, we tested the graft function and trough levels of immunosuppression in recipients. The clinical and follow-up data of 31 transplant recipients were analyzed.<br />Results: Compared with diseased controls (P=0.007) and healthy individuals (P=0.000), a notable expansion of CD8+CD28- Ts cells was found in recipients of A-A LDLT. This was associated with graft function, levels of immunosuppression and rejection episodes.<br />Conclusions: To monitor the CD8+CD28- Ts cells levels is important to evaluate the immune state of recipients. Meanwhile, it is also important to promote expansion of CD8+CD28- Ts cells in recipients of A-A LDLT, not only to sustain good graft function and decrease the dosage of immunosuppressants, but also to reduce the occurrence of rejection.
- Subjects :
- Adult
Female
Flow Cytometry
Follow-Up Studies
Graft Rejection
Humans
Immunosuppression Therapy
Liver Diseases complications
Liver Failure etiology
Liver Failure surgery
Liver Neoplasms classification
Liver Transplantation mortality
Male
Middle Aged
Young Adult
CD28 Antigens analysis
CD8-Positive T-Lymphocytes immunology
Liver Transplantation immunology
Living Donors
Subjects
Details
- Language :
- English
- ISSN :
- 1499-3872
- Volume :
- 8
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Hepatobiliary & pancreatic diseases international : HBPD INT
- Publication Type :
- Academic Journal
- Accession number :
- 19502162